Current Medicinal Chemistry
Current Medicinal Chemistry
4 years ago

Hairy root cultures for the production of anti-cancer naphthoquinone compounds.

Sykłowska-Baranek K, Jeziorek M, Pietrosiuk A
Anti-cancer studies of naphthoquinone derivatives are devoted to compounds isolated from natural plants or plant in vitro cultures, and also synthesized molecules. In this review, we focused on biotechnological efforts for optimization in vitro hairy root cultures for the production of anti-cancer naphthoquinones. Focusing on last decade tendencies we discovered that the most promising and intensively investigated compounds are shikonin and its derivatives, plumbagin and also rhinacanthin group or ramentaceone. We summarized most recent activity studies undertaken on anti-cancer naphthoquinones which could be produced in hairy root cultures. Reviewed natural plant compounds come from species of Boraginaceae, Plumbaginaceae, Droseraceae and Acanthaceae families.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28828978

DOI: PubMed:28828978

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