5 years ago

Immune checkpoint inhibitors: basics and challenges.

Chan HL, Li B, Chen P
Cancer is one of the most deadly diseases in modern world. The last decade has witnessed dramatic advances in the cancer treatment through immunotherapy. One extremely promising means to achieve anti-caner immunity is to block the immune checkpoint pathways, which mechanism was adopted by cancer cells to disguise themselves as regular components of human body. While checkpoint blockade is universally effective against a broad spectrum of cancer types and mostly unrestricted by certain gene mutation status, only a minority of patients achieved a complete response to such treatment. In this review we summarize the basic principles of immune checkpoint inhibitors and discuss potential mechanisms of resistance.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28782469

DOI: PubMed:28782469

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