Current Medicinal Chemistry
Current Medicinal Chemistry
4 years ago

Histone Deacetylase Inhibitors in Tumor Immunotherapy.

Zhao LM, Zhang JH
With an increasing understanding of the antitumor immune response, considerable progress has been made in the field of tumor immunotherapy in the last decade. Inhibition of HDACs represents a new strategy in tumor therapy and HDAC inhibitors have been recently developed and validated as potential antitumor drugs. In addition to the direct antitumor effects, HDAC inhibitors have been found to have the ability to improve tumor recognition by immune cells that may contribute to their antitumor activity. These immunomodolutory effects are desirable, and their in-depth comprehension will facilitate the design of novel regimens with improved clinical efficacy. In this review, we summarize recent advances in the understanding of how HDAC inhibitors alter immune process and discuss their effects on various cytokines. We also discuss the challenges to optimize the use of these inhibitors as immune modulators in cancer treatment, which may be helpful for designing tumor immunotherapy trials involving HDAC inhibitors.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28762309

DOI: PubMed:28762309

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