5 years ago

Unleashing the Potential of 17O NMR Spectroscopy Using Mechanochemistry

Unleashing the Potential of 17O NMR Spectroscopy Using Mechanochemistry
Christian Bonhomme, Christel Gervais, Thomas-Xavier Métro, Anthony Martinez, Danielle Laurencin
17O NMR spectroscopy has been the subject of vivid interest in recent years, because there is increasing evidence that it can provide unique insight into the structure and reactivity of many molecules and materials. However, due to the very poor natural abundance of oxygen-17, 17O labeling is generally a prerequisite. This is a real obstacle for most research groups, because of the high costs and/or strong experimental constraints of the most frequently used 17O-labeling schemes. Here, we show for the first time that mechanosynthesis offers unique opportunities for enriching in 17O a variety of organic and inorganic precursors of synthetic interest. The protocols are fast, user-friendly, and low-cost, which makes them highly attractive for a broad research community, and their suitability for 17O solid-state NMR applications is demonstrated. Mechanochemistry is shown to be a fast, user-friendly, and cost-efficient method for the 17O isotopic labeling of a variety of compounds of synthetic interest. The labeling method opens the way to many future developments in 17O NMR spectroscopy.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201702251

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.