Current Medicinal Chemistry
Current Medicinal Chemistry
3 years ago

Post cardiovascular surgery atrial fibrillation. Biomarkers determining prognosis.

Ricci B, Manfrini O, Bugiardini R, Cenko E
New onset of atrial fibrillation (AF) after cardiovascular surgery is associated with increased risk of complications and length of hospital stay. Identification of patients at high risk of post cardiovascular surgery AF may help to act with preventive strategies having clinical and economic relevance. Many factors such as cardiac remodelling, changes in atrial pressure, surgery trauma, inflammation, oxidative stress, and sympathetic/parasympathetic activation have been implicated in the development of post cardiovascular surgery. On the basis of multifactorial mechanism underlining the onset of post cardiac surgery AF, several studies had investigated the predictive role of some serum biomarkers. The focus of this review is to summarize findings on biomarkers of myocardial fibrosis (PICP and PIIINP), profibrotic mediators (TGF-beta1), extracellular matrix remodeling (MMP-9), myocardial stretch (BNP and NTpro-BNP), inflammation (interleukins, c-reactive protein and sCD40L), and myocardial necrosis (high-sensitivity troponin T), for being used in clinical practice to stratify patient' risk of post-cardiovascular surgery AF.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28748762

DOI: PubMed:28748762

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