Current Medicinal Chemistry
Current Medicinal Chemistry
5 years ago

Potential triazole-based molecules for the treatment of neglected diseases.

Mantoani SP, Chierrito TPC, de Andrade P, Figueredo AS, Carvalho I
Neglected Diseases (NDs) affect million of people, especially the poorest population around the world. Several efforts to an effective treatment have proved insufficient at the moment. In this context, triazole derivatives have shown great relevance in medicinal chemistry due to a wide range of biological activities. This review aims to describe some of the most relevant and recent research focused on 1,2,3- and 1,2,4-triazole-based molecules targeting four expressive NDs: Chagas disease, Malaria, Tuberculosis and Leishmaniasis.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28748757

DOI: PubMed:28748757

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