3 years ago

The concept of skeletal muscle memory: evidence from animal and human studies

T Snijders, T Aussieker, A Holwerda, G Parise, LJC van Loon, LB Verdijk

Within the current paradigm of the myonuclear domain theory, it is postulated that a linear relationship exists between muscle fiber size and myonuclear content. The myonuclear domain is kept (relatively) constant by adding additional nuclei (supplied by muscle satellite cells) during muscle fiber hypertrophy and nuclear loss (by apoptosis) during muscle fiber atrophy. However, data from recent animal studies suggest that myonuclei that are added to support muscle fiber hypertrophy are not lost within various muscle atrophy models. Such myonuclear permanence has been suggested to constitute a mechanism allowing the muscle fiber to (re)grow more efficiently during retraining, a phenomenon referred to as 'muscle memory'. The concept of 'muscle memory by myonuclear permanence' has mainly been based on data attained from rodent experimental models. Whether the postulated mechanism also holds true in humans remains largely ambiguous. Nevertheless, there are several studies in humans that provide evidence to potentially support or contradict (parts of) the muscle memory hypothesis. The goal of the present review is to discuss the evidence for the existence of 'muscle memory' in both animal and human models of muscle fiber hypertrophy as well as atrophy. Furthermore, to provide additional insight in the potential presence of muscle memory by myonuclear permanence in humans, we present new data on previously performed exercise training studies. Finally, suggestions for future research are provided to establish whether muscle memory really exists in humans.

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