3 years ago

Design and Ultrasound Assisted Synthesis of Novel 1,3,4‐Oxadiazole Drugs for Anti‐Cancer Activity

Design and Ultrasound Assisted Synthesis of Novel 1,3,4‐Oxadiazole Drugs for Anti‐Cancer Activity
Priyanka Bhatt, Anik Sen, Anjali Jha

An ultrasound assisted multi‐component synthesis of a series of 2‐(N‐heterocycle) substituted 1,3,4‐oxadiazoles have been performed. A proper IR, UV, Mass and NMR spectral analysis supported the 12 synthesized novel compounds. Compound 5‐bromo‐1‐((4‐chlorophenyl)((5‐(4‐hydroxyphenyl)‐1,3,4‐oxadiazol‐2‐yl)amino)methyl) indoline‐2,3‐dione (D8), displayed significant cytotoxicity against all the three human cancer cell lines studied in this article (breast cancer cell line MCF‐7, colorectal cancer cell line HT‐29 and liver cancer cell line Hep G2) using MTT assay. Further in silico target hunting using Chem Mapper led to the identification of two important cancer targets; EGFR and CDK2 kinases. Compound D8 was studied in detail using AutoDock and displayed high binding energies with the two proteins. Quantum chemical calculations of the designed compound D8 at the active site with specific amino acids for both the proteins showed stronger interactions at the active sites similar to the docking studies.

Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/slct.201904412

DOI: 10.1002/slct.201904412

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.