3 years ago

Incidence of severe hypoglycemia and its association with serum adiponectin in Japanese patients with type 1 and insulin‐treated type 2 diabetes: the Fukuoka Diabetes Registry

Masanori Iwase, Yuji Komorita, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Masahito Yoshinari, Yutaro Oku, Taiki Higashi, Udai Nakamura, Takanari Kitazono

Aims

The incidence of severe hypoglycemia and its risk factors including an insulin‐sensitizing adipokine, adiponectin were prospectively investigated in Japanese patients with type 1 or insulin‐treated type 2 diabetes

Materials and Methods

207 participants with type 1 diabetes (mean age, 55years) and 1,396 with insulin‐treated type 2 diabetes (mean age, 65 years) from local diabetes registry were followed for 5 years (follow‐up rate 99%). Severe hypoglycemia was defined as events requiring the assistance of others for recovery from hypoglycemia.

Results

The incidence of severe hypoglycemia was 9.2 per 100 person‐year in those with type 1 diabetes and 2.3 per 100 person‐year in those with insulin‐treated type 2 diabetes, respectively. In type 1 diabetes, the risk was significant in those with history of severe hypoglycemia within a previous year, slow eating, and higher serum adiponectin (the highest vs. the lowest in quartile hazard ratio (HR) 2.36, 95%CI 1.22‐4.69). In insulin‐treated type 2 diabetes, the risk included age ≥ 65 years, history of severe hypoglycemia within a previous year, alcohol consumption ≥ 60 g/day, larger insulin dose, and higher serum adiponectin (the highest vs. the lowest in quartile, HR 2.95, 95%CI 1.22‐4.69). In all participants, the incidence of severe hypoglycemia increased along with serum adiponectin (age‐and sex‐adjusted HR 1.65 per 1SD increase of log serum adiponectin, 95% CI 1.45‐1.87).

Conclusions

The incidence of severe hypoglycemia was prospectively determined and the association between severe hypoglycemia and higher serum adiponectin was observed in Japanese patients with type 1 and insulin‐treated type 2 diabetes.

Open access
You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.