3 years ago

Genetic Polymorphism of Experimentally Produced Forms of Arterial Hypertension

O. E. Redina, V. A. Devyatkin, N. I. Ershov, A. L. Markel
The paper analyzes the distribution of polymorphic loci in rats of different hypertensive strains. When analyzing the transcribed loci of ISIAH rats and the corresponding loci of 11 other hypertensive strains/substrains of rats, the maximum frequency of occurrence of identical SNPs in different strains was 0.58 (i.e., in 7 of 12 hypertensive strains/substrains). The analysis of the genomic sequences of 11 hypertensive strains/substrains of rats, which model different forms of arterial hypertension, also did not reveal a single SNP common to all 11 hypertensive strains/substrains of rats taken in the analysis. Analysis of experimental data suggests that hypertension is a genetically heterogeneous disease.

Publisher URL: http://link.springer.com/article/10.1134/S1022795420020106

DOI: 10.1134/S1022795420020106

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