3 years ago

Response on DCE-MRI predicts outcome of salvage radiotherapy for local recurrence after radical prostatectomy

Giuseppe Sanguineti, Luca Bertini, Adriana Faiella, Maria Consiglia Ferriero, Simona Marzi, Alessia Farneti, Valeria Landoni
Tumori Journal, Ahead of Print.
Objective:To assess the predictive role of response on dynamic contrast enhancement on magnetic resonance imaging (DCE-MRI) of visible local lesions in the setting of salvage radiotherapy (sRT) after radical prostatectomy.Methods:All patients referred for sRT for biochemical failure after radical prostatectomy from February 2014 to September 2016 were considered eligible if they had been restaged with DCE-MRI and had been found to have a visible lesion in the prostatic bed, but no distant/nodal disease on choline positron emission tomography (PET)–computed tomography (CT). Eligible patients were contacted during follow-up and offered reimaging with serial DCE-MRI until lesion resolution. Complete response (CR) was defined as the disappearance of the target lesion on DCE-MRI; prostate-specific antigen (PSA) recurrence was defined as a 0.2 ng/mL PSA rise above the nadir. Median follow-up after sRT was 41.5 months (range, 12.1–61.2 months).Results:Fifty-nine patients agreed to undergo repeated DCE-MRI for a total of 64 studied lesions. Overall, 57 lesions (89.1%) showed a CR after 1 (51 patients) or 2 (6 patients) scans, while 7 lesions did not show any change (no response [NR]). At 42 months, no evidence of biochemical disease (bNED) survival was 74.7±6.4% and 64.3±21.0% for patients with CR and NR lesions, respectively (hazard ratio [HR], 3.181; 95% confidence interval [CI], 0.157–64.364; p = 0.451). When only patients treated with sRT without androgen deprivation were selected (n = 41), bNED survival rates at 42 months were 72.1±8.0% and 0, respectively (HR, 52.830; 95% CI, 1.893–1474.110; p = 0.020).Conclusions:Patients whose lesions disappear during follow-up have a better outcome than those with unchanged lesions after sRT alone.

Publisher URL: https://journals.sagepub.com/doi/abs/10.1177/0300891620908950

DOI: 10.1177/0300891620908950

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