Pharmacological Reviews
Pharmacological Reviews
5 years ago

Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders.

Aggarwal M, Nicholson CJ, Gao YZ, Degen CV, Morgan KG, Brozovich FV
The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases regulate contractility of the vascular smooth muscle cell and we place this within the context of whole body function. We also discuss the implications for personalized medicine and highlight specific potential target molecules that may provide opportunities for the future development of new therapeutics to regulate vascular function.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/27037223

DOI: PubMed:27037223

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