4 years ago

Antibiotic Resistance: Photo‐Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA (Adv. Sci. 6/2020)

Antibiotic Resistance: Photo‐Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA (Adv. Sci. 6/2020)
Jie Hui, Pu‐Ting Dong, Lijia Liang, Taraknath Mandal, Junjie Li, Erlinda R. Ulloa, Yuewei Zhan, Sebastian Jusuf, Cheng Zong, Mohamed N. Seleem, George Y. Liu, Qiang Cui, Ji‐Xin Cheng

In article number 1903117, Ji‐Xin Cheng and co‐workers report an endogenous chromophore‐based phototherapy platform to combat antibiotic‐resistance Staphylococcus aureus infections. Functional membrane microdomains of Staphylococcus aureus are catastrophically disrupted via photochemical decomposition of membrane‐bound carotenoid pigment, staphyloxanthin, thus reviving a broad spectrum of conventional antibiotics against Staphylococcus aureus.

Publisher URL: https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202070035

DOI: 10.1002/advs.202070035

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