3 years ago

Antioxidant capacity of major royal jelly proteins of honeybee (Apis mellifera) royal jelly

Antioxidant capacity of major royal jelly proteins of honeybee (<em>Apis mellifera</em>) royal jelly
Min Ji Park, Bo Yeon Kim, Yijie Deng, Hee Geun Park, Yong Soo Choi, Kwang Sik Lee, Byung Rae Jin

Major royal jelly proteins (MRJPs) of honeybee royal jelly (RJ) exhibit antimicrobial and antioxidant activities. Although MRJPs of Apis mellifera RJ (AmMRJPs) responsible for antibacterial activity have been identified, AmMRJPs with antioxidant effects remain to be elucidated. Here we identified and compared the antioxidant activities of purified recombinant AmMRJPs 1–7, which are expressed in baculovirus-infected insect cells. Antioxidant assays of recombinant AmMRJPs 1–7 against H2O2 revealed that AmMRJPs reduce caspase-3 activity and oxidative stress-induced cell apoptosis and lead to increased cell viability. Consistent with these results, AmMRJPs 1–7 exhibit 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activity and protect against oxidative DNA damage. These results indicate that AmMRJPs play a role as antioxidants in A. mellifera RJ.

Publisher URL: https://www.sciencedirect.com/science/article/pii/S1226861520300479

DOI: 10.1016/j.aspen.2020.03.007

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