3 years ago

p62 as a therapeutic target for tumor

p62 as a therapeutic target for tumor
Mengmin Tao, Tian Liu, Qidong You, Zhengyu Jiang

p62/SQSTM1 (hereafter as p62) is a stress-inducible cellular protein, which interacts with various signaling proteins to regulate a variety of cellular functions. Growing lines of evidence supported a critical role of p62 in tumorigenesis, and p62 may become a therapeutic target for tumor. In this review, we summarize biological functions of structural domains of p62, reported bioactive molecules targeting p62, and the relationship between p62 and tumorigenesis.

Publisher URL: https://www.sciencedirect.com/science/article/pii/S0223523420301987

DOI: 10.1016/j.ejmech.2020.112231

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