3 years ago

Timing of modulation of corticospinal excitability by heartbeat differs with interoceptive accuracy

Naofumi Otsuru, Shota Miyaguchi, Sho Kojima, Koya Yamashiro, Daisuke Sato, Hirotake Yokota, Kei Saito, Yasuto Inukai, Hideaki Onishi

Interoceptive inputs are ascending information from the internal body. Cortical activities have been shown to be elicited by interoceptive inputs from the heartbeat at approximately 200–600 ms after the R wave, and sensory processing is modulated by the heartbeat within the time window. However, the influence of interoceptive inputs and their timing on corticospinal excitability has not yet been fully elucidated. Moreover, in previous studies, individual differences in interoceptive accuracy—objective accuracy in detecting internal bodily sensations assessed by heartbeat perception tasks—can be considered as an important factor influencing cortical activities by the heartbeat. We therefore investigated the modulation of corticospinal excitability by the heartbeat and its timing by recording motor-evoked potentials elicited by transcranial magnetic stimulation of the primary motor cortex at various timings from the R wave. We also investigated the relationship between this modulation and individual interoceptive accuracy. We found a significant positive correlation between the modulation of corticospinal excitability at 200 ms after the R wave and interoceptive accuracy. Conversely, we found a significant negative correlation between the modulation of corticospinal excitability at 400 ms after the R wave and interoceptive accuracy. These results indicated that the corticospinal excitability was modulated at 200–400 ms after the R wave (systolic phase) and that the timing of excitatory or inhibitory states in the corticospinal pathway differed with interoceptive accuracy. Although the neural mechanism remains unclear, these findings may aid in determining new factors influencing corticospinal excitability.

Open access
You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.