Current Pharmaceutical Design
Current Pharmaceutical Design
5 years ago

Graphene-based nanomaterials: potential tools for neurorepair.

Ma CG, Li YH, Zhang GX, Xiao BG, Jiang WJ, Zhao JG, Wang Q
Graphene, with its outstanding electrical properties, large surface area, and excellent mechanical properties, is found in a wide variety of applications in biomimetic substrates and biomedicine, with the result that there is growing interest in the effect of graphene-based nanomaterials on neural cells. This review sums up current research on the effectiveness of graphene and its derivatives on neural cells. We emphasize the biocompatibility of graphene and its derivatives, and how they affect the behavior of neural cells, including adhesion, proliferation, neurite outgrowth and differentiation. In addition, we discuss at great length the literature on graphene-based nanomaterials for drug delivery applications. In addition to being an excellent drug carrier, graphene and its derivatives have good biocompatibility and promote neural cell adhesion, proliferation, neurite outgrowth and differentiation. While their in vivo effects on the nervous system remain to be explored, encouraging findings indicate that graphene-based nanomaterials have significant potential as novel therapies for neurodegenerative disease.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28847305

DOI: PubMed:28847305

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