5 years ago

The Structure of the Elusive Simplest Dipeptide Gly-Gly

The Structure of the Elusive Simplest Dipeptide Gly-Gly
Marcelino Varela, José L. Alonso, Carlos Cabezas
Among the hundreds of peptide compounds for which conformations have been determined by using different spectroscopic techniques, the structure of the simplest dipeptide glycylglycine (Gly-Gly) is conspicuously absent. Herein, for the first time, solid samples of Gly-Gly have been vaporized by laser ablation and three different structures have been revealed in a supersonic expansion by Fourier transform microwave spectroscopy. The intramolecular hydrogen bonding interactions that stabilize the observed forms have been established based on the 14N nuclear quadrupole hyperfine structure. We have illustrated how conformer interconversion distorts the equilibrium conformational distribution, giving rise to missing conformers in the conformational landscape. Exposed! Structural secrets of Gly-Gly: The conformational landscape of the simplest dipeptide glycylglycine (Gly-Gly) has been unveiled for the first time by laser ablation coupled with Fourier transform microwave spectroscopy. The three identified conformers along with those not observed because of conformer interconversion, provide the first global structural picture of Gly-Gly, which is, to some extent, dynamic.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201702425

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