Current Pharmaceutical Design
Current Pharmaceutical Design
5 years ago

Neuroprotection in hypoxic-ischemic brain injury targeting glial cells.

Capani F, Mucci S, Herrera MI, Kolliker-Frers R, Barreto GE
Brain injury constitutes a disabling health condition of several etiologies. One of the major causes of brain injury is hypoxia-ischemia. Until recently, pharmacological treatments were solely focused on neurons. In the last decades, glial cells started to be considered as alternative targets for neuroprotection. Novel treatments for hypoxia-ischemia intend to modulate reactive forms of glial cells, and/or potentiate their recovery response. In this review, we summarize these neuroprotective strategies in hypoxia-ischemia and discuss their mechanisms of action.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28748754

DOI: PubMed:28748754

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