Current Pharmaceutical Design
Current Pharmaceutical Design
5 years ago

Pivotal roles of Interleukin-17 as the Epicenter of Bone Loss Diseases.

Yang Y, Liao C, Zhang C
Bone remodelling is a strictly regulated dynamic process between bone resorption and bone formation. Many factors are involved in the process and affect the dynamic balance. Inflammation-mediated bone loss is a major feature of various bone diseases, including periodontitis, rheumatoid arthritis (RA) and spondyloarthritis (SpA). Interleukin-17 (IL-17) plays an important role in inflammatory bone disease and could be an attractive therapeutic target. This review focuses on the osteoclastic effects of IL-17 in different cell types and summarizes the current knowledge of IL-17 signalling pathways. Typical IL-17-mediated bone destruction disorders are examined. The review also provides an overview of possible strategies for therapeutic intervention for inflammatory loss of bone targeting IL-17.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28741455

DOI: PubMed:28741455

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