Journal of Virology
Journal of Virology
5 years ago

Epstein-Barr Virus LMP1 Mediated Oncogenicity.

Wang LW, Jiang S, Gewurz BE
Epstein-Barr virus Latent Membrane Protein 1 (LMP1) is expressed in multiple human malignancies, including nasopharynegeal carcinoma, Hodgkin and immunosuppression-associated lymphomas. LMP1 mimics CD40 signaling to activate multiple growth and survival pathways, in particular NF-κB. LMP1 has critical roles in EBV-driven B-cell transformation, and its expression causes fatal lymphoproliferative disease in immunosuppressed mice. Here, we review recent developments in studies of LMP1 signaling, LMP1-induced host dependency factors, mouse models of LMP1 lymphomagenesis and anti-LMP1 immunotherapy approaches.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28835489

DOI: PubMed:28835489

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