Journal of Organic Chemistry
Journal of Organic Chemistry
5 years ago

Yttrium-Catalyzed Tandem Intermolecular Hydroalkoxylation/Claisen Rearrangement

Yttrium-Catalyzed Tandem Intermolecular Hydroalkoxylation/Claisen Rearrangement
Jinxian Liu, Xin Liu, Bo Zhou, Tong-De Tan, Long Li, Long-Wu Ye
An efficient yttrium-catalyzed tandem intermolecular hydroalkoxylation/Claisen rearrangement has been developed, providing various γ,δ-unsaturated amides in generally good to excellent yields. Importantly, high Z/E selectivity and diastereoselectivity were achieved. Other notable features of this method include widespread availability of the substrates, compatibility with a broad range of functional groups, and mild reaction conditions.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01612

DOI: 10.1021/acs.joc.7b01612

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