Accounts of Chemical Research
Accounts of Chemical Research
5 years ago

Three Principles of Diversity-Generating Biosynthesis

Three Principles of Diversity-Generating Biosynthesis
Wenjia Gu, Eric W. Schmidt
Natural products are significant therapeutic agents and valuable drug leads. This is likely owing to their three-dimensional structural complexity, which enables them to form complex interactions with biological targets. Enzymes from natural product biosynthetic pathways show great potential to generate natural product-like compounds and libraries. Many challenges still remain in biosynthesis, such as how to rationally synthesize small molecules with novel structures and how to generate maximum chemical diversity.

Publisher URL: http://dx.doi.org/10.1021/acs.accounts.7b00330

DOI: 10.1021/acs.accounts.7b00330

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