5 years ago

Chloride-Tolerant Gold(I)-Catalyzed Regioselective Hydrochlorination of Alkynes

Chloride-Tolerant Gold(I)-Catalyzed Regioselective Hydrochlorination of Alkynes
Bo Xu, Gerald B. Hammond, Rene Ebule, Shengzong Liang
We have developed a highly regioselective homogeneous gold(I)-catalyzed anti-hydrochlorination of unactivated alkynes at room temperature. We have overcome the incompatibility between conventional cationic gold catalysts and chloride by using a hydrogen-bonding activation of the Au–Cl bond. This approach is scalable, exhibits excellent functional group tolerance, and can be conducted in open air.

Publisher URL: http://dx.doi.org/10.1021/acscatal.7b02567

DOI: 10.1021/acscatal.7b02567

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