3 years ago

Complexation-Assisted Continuous Crystallization of Isomeric Systems with Nanofiltration Recycle

Complexation-Assisted Continuous Crystallization of Isomeric Systems with Nanofiltration Recycle
Shankul Vartak, Allan S. Myerson
Selective complexation is used to increase the dimensions of the impurity molecule and sterically prevent its incorporation in the API lattice. Subsequent nanofiltration separates the larger impurity complex from the uncrystallized API in solution, which can be concentrated and recycled to enhance yield. This novel process allows for simultaneous improvement of yield and crystal purity in a continuous mode.

Publisher URL: http://dx.doi.org/10.1021/acs.cgd.7b01030

DOI: 10.1021/acs.cgd.7b01030

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.