Crystal Growth & Design
Crystal Growth & Design
5 years ago

Complexation-Assisted Continuous Crystallization of Isomeric Systems with Nanofiltration Recycle

Complexation-Assisted Continuous Crystallization of Isomeric Systems with Nanofiltration Recycle
Shankul Vartak, Allan S. Myerson
Selective complexation is used to increase the dimensions of the impurity molecule and sterically prevent its incorporation in the API lattice. Subsequent nanofiltration separates the larger impurity complex from the uncrystallized API in solution, which can be concentrated and recycled to enhance yield. This novel process allows for simultaneous improvement of yield and crystal purity in a continuous mode.

Publisher URL: http://dx.doi.org/10.1021/acs.cgd.7b01030

DOI: 10.1021/acs.cgd.7b01030

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