5 years ago

Developmental ERK Signaling Goes Digital

Developmental ERK Signaling Goes Digital
Coralie Dessauges, Olivier Pertz

Reporting in Developmental Cell, de la Cova et al. (2017) present a biosensor to measure ERK activity dynamics in C. elegans larvae. They find that fate decision signaling involves frequency-modulated, digital ERK activity pulses. These findings may explain how graded morphogen signals are converted into precise and robust cell fate patterns.

Publisher URL: http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30684-6

DOI: 10.1016/j.devcel.2017.08.023

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