mRNAs on the Move after Lunch
mRNA localization often contributes to translational control. Reporting in Science, Moor et al. (2017) now show that many mRNAs and ribosomes are asymmetrically distributed along the apical-basal axis of enterocytes. Remarkably, when starved mice are fed, mRNAs encoding ribosomal proteins rapidly move to the ribosome-rich apical side to activate translation.
Publisher URL: http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30677-9
DOI: 10.1016/j.devcel.2017.08.017
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