3 years ago

A DNA Crosslinker Collects Mitotic Chromosomes

A DNA Crosslinker Collects Mitotic Chromosomes
Mingxuan Sun, Rebecca Heald

Incorporating each set of daughter chromosomes into a single nucleus at the end of mitosis is essential for genome stability. In a recent Cell paper, Samwer et al. (2017) show that by non-covalently crosslinking DNA, BAF promotes chromosome coalescence, preventing nuclear membranes from enwrapping individual chromosomes to form micronuclei.

Publisher URL: http://www.cell.com/developmental-cell/fulltext/S1534-5807(17)30670-6

DOI: 10.1016/j.devcel.2017.08.010

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