4 years ago

The Androgen Receptor: Is It a Promising Target?

Tiffany A. Traina, Ayca Gucalp


A growing body of literature supports the conclusion that the androgen receptor (AR) plays an important role in breast cancer pathogenesis and may prove to be a relevant therapeutic target for patients with AR-driven breast cancer. This has been most apparent in the subset of patients with triple-negative breast cancer (TNBC), in whom approximately 50% of tumors may have androgen dependence. Recent phase 2 clinical trials of agents that antagonize AR or reduce androgen production have shown clinical benefit and efficacy to varying degrees. This review highlights three of these recent trials of AR+ TNBC and acknowledge ongoing research in this exciting area.

Publisher URL: https://link.springer.com/article/10.1245/s10434-017-5961-9

DOI: 10.1245/s10434-017-5961-9

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