3 years ago

C–H Alkylations of (Hetero)Arenes by Maleimides and Maleate Esters through Cobalt(III) Catalysis

C–H Alkylations of (Hetero)Arenes by Maleimides and Maleate Esters through Cobalt(III) Catalysis
Shengnan Han, Lutz Ackermann, Zhao Zhang, Jie Li, Mengyao Tang
Efficient cobalt(III)-catalyzed (hetero)aryl and alkenyl C–H hydroarylations of maleimides and maleate esters have been achieved under remarkably mild reaction conditions. Thus, the versatile cobalt(III) catalyst [Cp*CoI2(CO)] showed excellent atom−and step−economy as well as high chemo- and site-selectivity providing expedient access to pharmacologically useful succinimides with wide functional group tolerance.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01480

DOI: 10.1021/acs.orglett.7b01480

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