3 years ago

Dendritic Cells In Hepatitis and Liver Transplantation.

Crispe IN, Wu X, Soysa R
Dendritic cells (DCs) play a key role in innate immune responses, and are also the most effective cells for the activation of T cell immunity. They acquire antigen and process it, then display in on the cell surface bound in a non-covalent complex with HLA molecules of class I (HLA-A, B, C) and class II (HLA-DR). These cells are subdivided into three main subsets, two called myeloid or classical DCs of types 1 and 2, and one called plasmacytoid. The myeloid DCs process and present antigen, while the plasmacytoid DCs also strongly respond to viral signals by secreting Type 1 Interferon. In the liver, all of these subsets are present, but their relative abundance is different from the peripheral blood, and it is further modified by liver disease. It appears that in relation to T cell tolerance, both mDCs and pDCs are influenced by the liver milieu and promote T cell inactivation. However in anti-viral responses and in ischemia-reperfusion injury, where innate immune functions are more important, mDCs and pDCs have distinct roles. This article is protected by copyright. All rights reserved.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28752938

DOI: PubMed:28752938

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