Toxicological Sciences
Toxicological Sciences
5 years ago

Perturbation to Cholesterol at the Neuromuscular Junction confers botulinum neurotoxin A sensitivity to neonatal mice.

Baskaran P, Potian JG, Thyagarajan B, McArdle JJ
Botulinum neurotoxin A (BoNT/A) cleaves SNAP25 at the motor nerve terminals and inhibits stimulus evoked acetylcholine release. This causes skeletal muscle paralysis. However, younger neonatal mice (P7) mice. However, neonatal mice younger than 7 days-age remained unaffected by BoNT/A injection. Also, BoNT/A inhibited stimulus evoked acetylcholine release and stimulus-evoked twitch tension of diaphragm nerve muscle preparations (NMPs) of adult mouse and >P7 neonates but not that of P7. However, cholesterol depletion using methyl-β-cyclodextrin (MβCD) sensitized

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28645175

DOI: PubMed:28645175

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