3 years ago

Construction of carbocycles initiated by Cu-catalyzed radical reaction of Cl2C(CN)2

Construction of carbocycles initiated by Cu-catalyzed radical reaction of Cl2C(CN)2
A Cu-catalyzed radical reaction of Cl2C(CN)2 was utilized for stereoselective conversion of unsaturated molecules into functionalized carbocycles. Chloromalononitrile radicals, generated by treating Cl2C(CN)2 with catalytic amounts of CuCl and dppf in refluxing dioxane, intermolecularly reacted with the unsaturated bonds of acyclic or 10-membered compounds. The resultant carboradicals then intramolecularly added to another unsaturated bond to produce 1,2-disubstituted cyclopentane or trans-decalin derivatives. The chemo- and stereoselectivities of these radical cascade reactions are discussed in detail.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017303125

You might also like
Never Miss Important Research

Researcher is an app designed by academics, for academics. Create a personalised feed in two minutes.
Choose from over 15,000 academics journals covering ten research areas then let Researcher deliver you papers tailored to your interests each day.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.