Tetrahedron
Tetrahedron
5 years ago

Oxidative cleavage of hydroxamic acid promoted by sodium periodate

Oxidative cleavage of hydroxamic acid promoted by sodium periodate
A series of hydroxamic acids, involving aliphatic, aromatic and cyclic substrates, were transformed to the corresponding carboxylic acids through NaIO4-mediated oxidative cleavage in mild conditions. Esterification of these acids with TMSCHN2 could result in formation of the corresponding methyl ester. This methodology makes good compensation for the existing methods transforming amides to esters. Our results also pave the way to harness hydroxamic acids as useful synthetic building blocks.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017303307

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