3 years ago

Biomimetic synthesis of myrtucommulone K, N and O

Biomimetic synthesis of myrtucommulone K, N and O
A concise total synthesis of myrtucommulone K, N and O have been developed in 4 steps from commercially available materials. The synthetic strategy was inspired primarily by the biogenetic hypothesis and firstly enabled via a reduction, dehydration sequence for preparing isobutylidenesyncarpic acid followed by a hetero-Diels-Alder reaction to disclose the target moleculars. In this approach the exocyclic double bond of (−)-β-caryophyllene was more active than the endocyclic one in hetero-Diels–Alder reaction as the dienophile. The route is protecting-group-free, concise step, redox and pot economy.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017304738

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.