3 years ago

Enantioselective synthesis of crotyl geminal bis(silane) and its usage for asymmetric Sakurai allylation of acetals

Enantioselective synthesis of crotyl geminal bis(silane) and its usage for asymmetric Sakurai allylation of acetals
Enantioselective synthesis of crotyl geminal bis(silane) 4 has been developed by an asymmetric [1, 5]-hydride shift of allylic hydrazine. SnCl4-promoted Sakurai allylation of (R)-4 with acetals leads to chemoselective desilylation of SiMe3, generating E-syn-(S, R)-5 in good yields with high E/Z-, diastereo- and enantioselectivity.

Publisher URL: www.sciencedirect.com/science

DOI: S0040402017304775

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.