Fertility and Sterility
Fertility and Sterility
5 years ago

Endometriosis and obstetrics complications: a systematic review and meta-analysis

To evaluate the effect of endometriosis on pregnancy outcomes. Design Systematic review and meta-analysis. Setting Not applicable. Patient(s) Women with or without endometriosis. Intervention(s) Electronic databases searched from their inception until February 2017 with no limit for language and with all cohort studies reporting the incidence of obstetric complications in women with a diagnosis of endometriosis compared with a control group (women without a diagnosis of endometriosis) included. Mean Outcome Measure(s) Primary outcome of incidence of preterm birth at <37 weeks with meta-analysis performed using the random effects model of DerSimonian and Laird to produce an odds ratio (OR) with 95% confidence interval (CI). Result(s) Twenty-four studies were analyzed comprising 1,924,114 women. In most of them, the diagnosis of endometriosis was made histologically after surgery. Women with endometriosis had a statistically significantly higher risk of preterm birth (OR 1.63; 95% CI, 1.32–2.01), miscarriage (OR 1.75; 95% CI, 1.29–2.37), placenta previa (OR 3.03; 95% CI, 1.50–6.13), small for gestational age (OR 1.27; 95% CI, 1.03–1.57), and cesarean delivery (OR 1.57; 95% CI, 1.39–1.78) compared with the healthy controls. No differences were found in the incidence of gestational hypertension and preeclampsia. Conclusion(s) Women with endometriosis have a statistically significantly higher risk of preterm birth, miscarriage, placenta previa, small for gestational age infants, and cesarean delivery.

Publisher URL: www.sciencedirect.com/science

DOI: S0015028217305393

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.