3 years ago

Advances in Audio-Based Systems to Monitor Patient Adherence and Inhaler Drug Delivery.

Reilly RB, Sulaiman I, Costello RW, Zigel Y, Taylor TE, De Looze C
Hundreds of millions of people suffer from asthma and chronic obstructive pulmonary disease (COPD) worldwide. Current medications to control these chronic respiratory diseases can be administered using inhaler devices, such as the pressurized metered dose inhaler (pMDI) and dry powder inhaler (DPI). Providing that they are used as prescribed, inhalers can improve patients' clinical outcomes and quality of life. Poor patient inhaler adherence (both time of use and user technique) is, however, a major clinical concern and is associated with poor disease control, increased hospital admissions and increased mortality rates, particularly in low-middle income countries. There are currently limited methods available to healthcare professionals to objectively and remotely monitor patient inhaler adherence. This review describes recent sensor-based technologies that use audio-based approaches that show promising opportunities for monitoring inhaler adherence in clinical practice. This review discusses how one form of sensor-based technology, audio-based monitoring systems, can provide clinically pertinent information regarding patient inhaler use over the course of treatment. Audio-based monitoring can provide healthcare professionals with quantitative measurements of the drug delivery of inhalers signifying a clear clinical advantage over other methods of assessment. Furthermore, objective audio-based adherence measures can improve the predictability of patient outcomes to treatment compared to current standard methods of adherence assessment used in clinical practice. Objective feedback on patient inhaler adherence can be used to personalize treatment to the patient which may enhance precision medicine in the treatment of chronic respiratory diseases.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28887061

DOI: PubMed:28887061

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