5 years ago

HHV8 and Kaposi's sarcoma: should we really give up protease inhibitors in all HIV-infected patients?

Allemand, Julie, Philibert, Patrick, Halfon, Philippe, Delord, Marion, Khiri, Hacène, Retornaz, Frédérique, Chiche, Laurent, Stavris, Chloé, Rebaudet, Stanislas, Caillères, Sylvie
image We describe the first case of a patient presenting Kaposi's sarcoma with human herpes virus 8 (HHV8) viremia after switching from a protease inhibitor to an integrase inhibitor-based combination antiretroviral therapy, followed by a rapid remission when resuming protease inhibitor. We suggest that the recent recommendations to switch all HIV patients to protease inhibitor-free regimens should be carefully re-evaluated especially in MSM HIV patients which are at higher risks of HHV8 infections and associated malignancies.
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