3 years ago

Electrical Stimulation Reduces Smokers' Craving by Modulating the Coupling between Dorsal Lateral Prefrontal Cortex and Parahippocampal Gyrus.

Wang Y, Zhang X, Zhang W, Shi B, Ji X, Lv W, Liu Y, Yang LZ, Hudak J, Li H, Zhou Y, Fallgatter AJ
Applying electrical stimulation over the prefrontal cortex can help nicotine dependents reduce cigarette craving. However, the underlying mechanism remains ambiguous. The present study investigates this issue with functional magnetic resonance imaging. Thirty-two male chronic smokers received real and sham stimulation over dorsal lateral prefrontal cortex separated by 1 week. The neuroimaging data of the resting state, the smoking cue reactivity task and the emotion task after stimulation were collected. The craving across the cue reactivity task was diminished during real stimulation as compared to sham stimulation. The whole-brain analysis on the cue reactivity task revealed a significant interaction between the stimulation condition (real vs. sham) and the cue type (smoking vs. neutral) in the left superior frontal gyrus and the left middle frontal gyrus. The functional connectivity between the left dorsal lateral prefrontal cortex and the right parahippocampal gyrus, as revealed by both psychophysical interaction analysis and the resting state functional connectivity, is altered by electrical stimulation. Moreover, the craving change across the real and sham condition is predicted by alteration of functional connectivity revealed by psychophysical interaction analysis. The local and long-distance coupling, altered by the electrical stimulation, might be the underlying neural mechanism of craving regulation.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28398588

DOI: PubMed:28398588

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