Social Cognitive and Affective Neuroscience
Social Cognitive and Affective Neuroscience
5 years ago

Electrical Stimulation Reduces Smokers' Craving by Modulating the Coupling between Dorsal Lateral Prefrontal Cortex and Parahippocampal Gyrus.

Wang Y, Zhang X, Zhang W, Shi B, Ji X, Lv W, Liu Y, Yang LZ, Hudak J, Li H, Zhou Y, Fallgatter AJ
Applying electrical stimulation over the prefrontal cortex can help nicotine dependents reduce cigarette craving. However, the underlying mechanism remains ambiguous. The present study investigates this issue with functional magnetic resonance imaging. Thirty-two male chronic smokers received real and sham stimulation over dorsal lateral prefrontal cortex separated by 1 week. The neuroimaging data of the resting state, the smoking cue reactivity task and the emotion task after stimulation were collected. The craving across the cue reactivity task was diminished during real stimulation as compared to sham stimulation. The whole-brain analysis on the cue reactivity task revealed a significant interaction between the stimulation condition (real vs. sham) and the cue type (smoking vs. neutral) in the left superior frontal gyrus and the left middle frontal gyrus. The functional connectivity between the left dorsal lateral prefrontal cortex and the right parahippocampal gyrus, as revealed by both psychophysical interaction analysis and the resting state functional connectivity, is altered by electrical stimulation. Moreover, the craving change across the real and sham condition is predicted by alteration of functional connectivity revealed by psychophysical interaction analysis. The local and long-distance coupling, altered by the electrical stimulation, might be the underlying neural mechanism of craving regulation.

Publisher URL: https://www.ncbi.nlm.nih.gov/pubmed/28398588

DOI: PubMed:28398588

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.