3 years ago

Transition-Metal-Catalyzed Utilization of Methanol as a C1 Source in Organic Synthesis

Transition-Metal-Catalyzed Utilization of Methanol as a C1 Source in Organic Synthesis
Helfried Neumann, Matthias Beller, Kishore Natte, Rajenahally V. Jagadeesh
Methanol is used as a common solvent, cost-effective reagent, and sustainable feedstock for value-added chemicals, pharmaceuticals, and materials. Among the various applications, the utilization of methanol as a C1 source for the formation of carbon–carbon, carbon–nitrogen, and carbon–oxygen bonds continues to be important in organic synthesis and drug discovery. In particular, the synthesis of C-, N-, and O-methylated products is of central interest because these motifs are found in a large number of natural products as well as fine and bulk chemicals. In this Minireview, we summarize the utilization of methanol as a C1 source in methylation, methoxylation, formylation, methoxycarbonylation, and oxidative methyl ester formation reactions. Sustainable C1 source: Methanol serves as a sustainable feedstock for value-added chemicals, materials, and life science molecules. It has also been used as a C1 source in methylation, methoxylation, formylation, methoxycarbonylation, and oxidative methyl ester formation reactions for the synthesis of C-methylated products, N-methylamines, formamides, urea derivatives, ethers, esters, and heterocycles.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201612520

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