5 years ago

Lipid Emulsion in Local Anesthetic Toxicity: Long-winded, Rude, and Right

Harvey, M., Cave, G.
(Anesthesiology. 2016;125(3):451–453) This editorial accompanied the article by Dureau et al and reviewed some of the theories regarding the antidotal mechanism of lipid emulsions in local anesthetic toxicity (LAST). The “lipid sink” theory postulates that sequestration of lipophilic local anesthetics into a newly created intravascular lipid phase may counter cardiotoxicity. However, this theory is now thought to be an oversimplification and not fully true based on results from extensive pharmacokinetic and pharmacodynamic trials.
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