JACC: Cardiovascular Interventions
JACC: Cardiovascular Interventions
5 years ago

Stenting of the Right Ventricular Outflow Tract Promotes Better Pulmonary Arterial Growth Compared With Modified Blalock-Taussig Shunt Palliation in Tetralogy of Fallot–Type Lesions

Stenting of the Right Ventricular Outflow Tract Promotes Better Pulmonary Arterial Growth Compared With Modified Blalock-Taussig Shunt Palliation in Tetralogy of Fallot–Type Lesions
This study sought to compare pulmonary arterial (PA) growth during palliation after right ventricular outflow tract (RVOT) stenting versus modified Blalock-Taussig shunt (mBTS) in patients coming forward for complete repair of tetralogy of Fallot–type lesions. Background RVOT stenting is a recent alternative to mBTS in the initial palliation of selected patients with Fallot-type lesions. Methods This was a retrospective, single-center study of nonrandomized, consecutive palliated Fallot patients over a 10-year period. Differential left PA (LPA) and right PA (RPA) growth was assessed by serial echocardiograms in 67 patients after mBTS (n = 28) or RVOT stent (n = 39). Statistical data analysis was performed using mixed model analysis. Results RPA z-scores in the mBTS group improved from median −2.41 (interquartile range [IQR]: −2.97 to −1.32) to −1.13 (IQR: −1.68 to −0.59). LPA z-scores improved from −1.89 (IQR: −2.33 to −1.12) to −0.32 (IQR: −0.88 to −0.05). In the RVOT stenting group RPA z-scores improved from −2.28 (IQR: −3.28 to −1.82) to −0.72 (IQR: −1.27 to +0.48), and LPA z-scores from −2.08 (IQR: −2.90 to −0.61) to −0.05 (IQR: −0.88 to +0.48). Mixed model analysis showed significantly better RPA and LPA growth after RVOT stenting. The benefit of RVOT stenting versus mBTS was 0.599 z-scores for the LPA and 0.749 z-scores for the RPA. Rise in oxygen saturations was greater with RVOT stenting (p = 0.012). Median time to complete repair was shorter in the RVOT stent group (227 [142 to 328] days) compared with the mBTS group (439 [300 to 529] days; p < 0.0003). Conclusions RVOT stenting promotes better pulmonary arterial growth and oxygen saturations compared with mBTS in the initial palliation of Fallot-type lesions.

Publisher URL: www.sciencedirect.com/science

DOI: S193687981731244X

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