International Journal of Antimicrobial Agents
International Journal of Antimicrobial Agents
5 years ago

In vitro and in vivo assessment of newer quinoxaline–oxadiazole hybrids as antimicrobial and antiprotozoal agents

In vitro and in vivo assessment of newer quinoxaline–oxadiazole hybrids as antimicrobial and antiprotozoal agents
A new series of N-(substituted-phenyl)-2-[5-(quinoxalin-2-yloxymethyl)-[1,3,4] oxadiazol-2-ylsulfanyl]-acetamides (5a–o) was designed and synthesised from the parent compound 2-hydroxy quinoxaline (1) through a multistep reaction sequence and was characterised by spectral and elemental analyses. All of the compounds synthesised were evaluated for their antimicrobial and antiprotozoal activities. The results revealed that quinoxaline-based 1,3,4-oxadiazoles displayed promising antibacterial, antifungal and anti-Trypanosoma cruzi activities compared with reference drugs, particularly the lead compound 5l in a short-term in vivo model in T. cruzi.

Publisher URL: www.sciencedirect.com/science

DOI: S0924857917302248

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