Organic Letters
Organic Letters
5 years ago

Ruthenium-Catalyzed Synthesis of Fused Tricyclic 1H-2,3-Dihydropyrimido[1,2-a]quinolines in One Step

Ruthenium-Catalyzed Synthesis of Fused Tricyclic 1H-2,3-Dihydropyrimido[1,2-a]quinolines in One Step
Xingyong Wang, Xinyan Wang, Yuefei Hu, Xiaobao Zeng, Chulong Liu, Xuesong Wang
A novel ruthenium-catalyzed intramolecular cyclization of a nitrile and an azetidine was developed to achieve a one-step synthesis of the fused tricyclic 1H-2,3-dihydropyrimido[1,2-a]quinoline, which is the core skeleton for more than 100 natural pyoverdines and is also responsible for their fluorescence.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b01330

DOI: 10.1021/acs.orglett.7b01330

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