4 years ago

Cobalt(III)-Catalyzed Fast and Solvent-Free C–H Allylation of Indoles Using Mechanochemistry

Cobalt(III)-Catalyzed Fast and Solvent-Free C–H Allylation of Indoles Using Mechanochemistry
Xinpeng Jiang, Chuanming Yu, Weijie Zhu, Wei-Ke Su, Yong Liu, Kang Cheng, Jinkang Chen
Mechanochemical conditions have been applied to a highly efficient cobalt(III)-catalyzed C–H bond activation for the first time. In a subsequent step to the olefin insertion and β-oxygen elimination, N-pyrimidinylindoles were allylated with vinylethylene carbonates in the absence of organic solvent under high-speed ball-milling condition. As the reaction afforded the desired products in up to 98% yields within a short time, this method constitutes an environmentally friendly and powerful alternative to the common solution-based approaches.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01695

DOI: 10.1021/acs.joc.7b01695

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.