Journal of Organic Chemistry
Journal of Organic Chemistry
4 years ago

Cobalt(III)-Catalyzed Fast and Solvent-Free C–H Allylation of Indoles Using Mechanochemistry

Cobalt(III)-Catalyzed Fast and Solvent-Free C–H Allylation of Indoles Using Mechanochemistry
Xinpeng Jiang, Chuanming Yu, Weijie Zhu, Wei-Ke Su, Yong Liu, Kang Cheng, Jinkang Chen
Mechanochemical conditions have been applied to a highly efficient cobalt(III)-catalyzed C–H bond activation for the first time. In a subsequent step to the olefin insertion and β-oxygen elimination, N-pyrimidinylindoles were allylated with vinylethylene carbonates in the absence of organic solvent under high-speed ball-milling condition. As the reaction afforded the desired products in up to 98% yields within a short time, this method constitutes an environmentally friendly and powerful alternative to the common solution-based approaches.

Publisher URL: http://dx.doi.org/10.1021/acs.joc.7b01695

DOI: 10.1021/acs.joc.7b01695

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