4 years ago

Erythrocyte Membrane-Wrapped pH Sensitive Polymeric Nanoparticles for Non-Small Cell Lung Cancer Therapy

Erythrocyte Membrane-Wrapped pH Sensitive Polymeric Nanoparticles for Non-Small Cell Lung Cancer Therapy
Jinge Zhou, Ting Peng, Lei Yu, Yiting Wang, Jihong Sun, Jing Wang, Ye Xiao, Weiyue Lu, Lipeng Gao, Lijuan Nan, Hao Wang, Lin Zhang, Zhiqiang Yan, Lei Sun
The application of nano drug delivery systems (NDDSs) may enhance the effectiveness of chemotherapeutic drugs in vivo. However, the short blood circulation time and poor drug release profile in vivo are still two problems with them. Herein, by using red blood cell membrane (RBCm) wrapping and pH sensitive technology, we prepared RBCm wrapped pH sensitive poly(l-γ-glutamylcarbocistein)-paclitaxel (PGSC–PTX) nanoparticles (PGSC–PTX@RBCm NPs), to prolong the circulation time in blood and release PTX timely and adequately in acidic tumor environment. The PGSC–PTX NPs and PGSC–PTX@RBCm NPs showed spherical morphology with average sizes about 50 and 100 nm, respectively. The cytotoxicity of PGSC–PTX@RBCm NPs was considerably decreased compared with that of PGSC–PTX NPs. PTX release from PGSC–PTX and PGSC–PTX@RBCm NPs at pH 6.5 was remarkably higher than those at pH 7.4, respectively. The PGSC–PTX@RBCm NPs exhibited remarkably decreased uptake by macrophages than PGSC–PTX NPs. The area under the curve within 72 h (AUC0–72h) for is significantly higher than PGSC–PTX NPs. The PGSC–PTX@RBCm NPs also showed significantly stronger growth-inhibiting effect on tumor than PGSC–PTX NPs. These results indicated that PGSC–PTX@RBCm NPs have acidic drug release sensitivity, the characteristics of long circulation, and remarkable tumor growth inhibiting effect. This study may provide an effective strategy for improving the antitumor effect of NDDS.

Publisher URL: http://dx.doi.org/10.1021/acs.bioconjchem.7b00428

DOI: 10.1021/acs.bioconjchem.7b00428

You might also like
Discover & Discuss Important Research

Keeping up-to-date with research can feel impossible, with papers being published faster than you'll ever be able to read them. That's where Researcher comes in: we're simplifying discovery and making important discussions happen. With over 19,000 sources, including peer-reviewed journals, preprints, blogs, universities, podcasts and Live events across 10 research areas, you'll never miss what's important to you. It's like social media, but better. Oh, and we should mention - it's free.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.