3 years ago

Modular Approach to pseudo-Neoclerodanes as Designer κ-Opioid Ligands

Modular Approach to pseudo-Neoclerodanes as Designer κ-Opioid Ligands
Thomas E. Prisinzano, Samuel E. Williamson, Alexander M. Sherwood, Logan M. Abbott, Victor W. Day, Rachel S. Crowley
Informed by previous semisynthetic work on salvinorin A, a modular total synthesis has been developed capable of producing novel compounds targeting the κ-opioid receptor. The strategy has permitted the deliberate simplification and introduction of functionality about the target molecule to provide access to molecular features on salvinorin A otherwise unattainable by semisynthesis. Using this approach, a potent pseudo-neoclerodane κ-opioid receptor ligand (2) has been realized.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02684

DOI: 10.1021/acs.orglett.7b02684

You might also like
Never Miss Important Research

Researcher is an app designed by academics, for academics. Create a personalised feed in two minutes.
Choose from over 15,000 academics journals covering ten research areas then let Researcher deliver you papers tailored to your interests each day.

  • Download from Google Play
  • Download from App Store
  • Download from AppInChina

Researcher displays publicly available abstracts and doesn’t host any full article content. If the content is open access, we will direct clicks from the abstracts to the publisher website and display the PDF copy on our platform. Clicks to view the full text will be directed to the publisher website, where only users with subscriptions or access through their institution are able to view the full article.