3 years ago

Intramolecular Pd-Catalyzed Anomeric C(sp3)–H Activation of Glycosyl Carboxamides

Intramolecular Pd-Catalyzed Anomeric C(sp3)–H Activation of Glycosyl Carboxamides
NourEddine Ghermani, Vincent Gandon, Samir Messaoudi, Mouâd Alami, Nicolas Probst, Gwendal Grelier
An expedient method for the synthesis of fused glycosylquinolin-2-ones and glycosylspirooxindoles through an unprecedented intramolecular Pd-catalyzed anomeric C–H activation of the sugar moiety of 2-bromophenyl glycosylcarboxamides is reported. The scope of the reaction is broad and tolerates a wide range of functional groups.

Publisher URL: http://dx.doi.org/10.1021/acs.orglett.7b02170

DOI: 10.1021/acs.orglett.7b02170

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