Angewandte Chemie - International Edition
Angewandte Chemie - International Edition
5 years ago

Pseudouridimycin: the first Nucleoside Analogue that Selectively Inhibits Bacterial RNA Polymerase

Pseudouridimycin: the first Nucleoside Analogue that Selectively Inhibits Bacterial RNA Polymerase
Mathieu F. Chellat, Rainer Riedl
Seek, and ye shall find: After years of focusing research on synthetic antibiotics out of fear that all the useful natural ones had already been found, a novel antibacterial compound has been discovered through conventional microbial extract screening. The broad-spectrum nucleoside-analogue inhibitor pseudouridimycin is selective for bacterial RNA polymerase and elicits very low resistance rates.

Publisher URL: http://onlinelibrary.wiley.com/resolve/doi

DOI: 10.1002/anie.201708133

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